At the Laboratory for Stem Cell Research (LSR) we are investigating adipose-derived stem cells (ASCs) for the development of innovative therapeutic tools for a variety of conditions. Clinical studies have shown that ASCs can be used as an effective treatment for a variety of immune/inflammatory diseases, such as osteoarthritis and Crohn’s disease. These positive results are believed to be mediated by the inhibitory effect of ASCs on the activity of immune cells such as monocytes, T and B lymphocytes, and dendritic cells. The predominant mechanism by which ASCs interact with these target cells seems to be related the large number of growth factors and cytokines released by the ASCs. Recent studies, however, attribute the main immunosuppressive role to lipid microvesicles secreted by the cells. In our laboratory, we use in vitro models to investigate the effects of the different factors (soluble factors and microvesicles) secreted by adipose-derived stem cells (ASCs) on the response of innate immune cells.
Follow us on Facebook and LinkedIn