Research focus has been the involvement of the fatty acid transporter CD36 in ectopic fat accumulation in obesity and DM2, sCD36 as a marker for this process and the relationship between ectopic fat in various organs, insulin resistance and sCD36. Recently, we have worked on establishing a method for measurement of circulating microvesicles, and investigated their potential role in atherosclerosis and insulin resistance.
Liver-derived Microvesicles – Rare Events in Liquid Biopsies as Novel Biomarkers for Non-alcoholic Fatty Liver Disease
My research focus is to study levels and the plasma-membrane sub-proteome of circulating liver-derived microvesicles (MVs) as possible biomarkers for the development and progression of non-alcoholic fatty liver disease (NAFLD). I am further interested in characterising liver-derived MV expression of plasma membrane proteins that are involved in the metabolic syndrome and type 2 diabetes mellitus, including the fatty acid transporter CD36.
Research Technician (Aarhus University Hospital)
New Biomarkers for Atherosclerotic Plaques
The aim of my research is to measure microvesicles (MV) released from monocytes, platelets, and endothelial cells from patients with atherosclerotic plaques. The presence of the scavenger receptor CD36, that plays a key role in accumulation of cholesterol in the vessel wall, will be investigated on MVs and the focus of the project will be to develop methods to find new biomarkers for atherosclerosis.
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